Advances in tooth development studies based on single-cell RNA sequencing
10.3760/cma.j.cn112144-20240927-00363
- VernacularTitle:单细胞转录组测序技术在牙齿发育研究中的应用与进展
- Author:
Nan JIANG
1
;
Xutong ZHU
1
;
Yan LIU
1
Author Information
1. 北京大学口腔医学院·口腔医院中心实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心 口腔生物材料和数字诊疗装备国家工程研究中心 口腔数字医学北京市重点实验室，北京 100081
- Publication Type:Journal Article
- Keywords:
Genomics;
Tooth development;
Single-cell RNA sequencing;
Transcriptomics;
Subgroup;
Marker genes
- From:
Chinese Journal of Stomatology
2025;60(1):75-80
- CountryChina
- Language:Chinese
-
Abstract:
Tooth development is a complex process of the orderly interaction between epithelium originating from the ectoderm and mesenchyme derived from cranial neural crest cells, which not only depends on cell genes regulatory network but also involves crosstalk between cells and their surrounding environment. Even within the same type of cellular populations, obvious heterogeneity may be observed. Single-cell RNA sequencing is a novel technology aimed at sequencing the transcriptome of individual cell. As a critical bridge linking genetic information from the genome to the functional proteome, transcriptome analysis at the single-cell level enables a deeper understanding of cellular heterogeneity and organ developmental trajectories. This approach provides a powerful tool for elucidating complex biological processes and identifying potential therapeutic targets. Here, we summarize the latest advances in employing single-cell RNA sequencing analysis to the process of tooth development, which will help provide insights into a better understanding of prosthodontics and regeneration.
