The value of quantitative parameters of dual-layer detector spectral CT in prediction of Ki-67 expression in solid lung adenocarcinoma
10.3969/j.issn.1002-1671.2025.03.010
- VernacularTitle:双层探测器光谱CT定量参数预测实性肺腺癌Ki-67表达的价值
- Author:
Jinping MA
1
;
Xiaoxu GUO
1
;
Hui WANG
1
;
Limin LEI
1
;
Lina TAO
1
;
Yajie WANG
1
;
Songwei YUE
1
Author Information
1. 郑州大学第一附属医院放射科,河南 郑州 450052
- Publication Type:Journal Article
- Keywords:
lung adenocarcinoma;
Ki-67;
dual-layer detector spectral CT
- From:
Journal of Practical Radiology
2025;41(3):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of quantitative parameters of dual-layer detector spectral CT(DLCT)for Ki-67 expression in solid lung adenocarcinoma.Methods The data of 103 patients were retrospectively collected,and the patients were divided into Ki-67 high expression and Ki-67 low expression groups according to Ki-67 proliferation index.The quantitative parame-ters of DLCT were measured and calculated,and the differences in these parameters between the two groups were compared.The parameters with statistically significant differences were assessed for correlation with Ki-67 expression.The efficacy of DLCT param-eters and combined parameters in predicting Ki-67 expression in solid lung adenocarcinoma were evaluated by receiver operating character-istic(ROC)curve and compared by DeLong test.Results Long diameter,short diameter and smoking history were positively corre-lated with the Ki-67 expression in solid lung adenocarcinoma(r>0,P<0.05).Gender and quantitative parameters of DLCT were nega-tively correlated with the Ki-67 expression in solid lung adenocarcinoma(r<0,P<0.05).The combined parameters of convention and spectral CT had the highest prediction efficiency.Conclusion The quantitative parameters of DLCT can be used to evaluate the Ki-67 expres-sion in solid lung adenocarcinoma.
