Minocycline-induced increased intracranial pressure in a child
10.3760/cma.j.cn114015-20241206-00185
- VernacularTitle:米诺环素致儿童颅内压增高
- Author:
Longxi PENG
1
;
Zhengxiang LI
1
;
Hengjie YUAN
1
Author Information
1. 天津医科大学总医院药剂科，天津 300052
- Publication Type:Journal Article
- Keywords:
Minocycline;
Intracranial pressure;
Child;
Adverse drug reactions
- From:
Adverse Drug Reactions Journal
2025;27(8):502-504
- CountryChina
- Language:Chinese
-
Abstract:
A 12-year-old male child with severe pneumonia received anti-infection therapy with cefoperazone sodium and sulbactam sodium (3 g by intravenous infusion, once every 8 hours) and minocycline (100 mg twice daily orally). After 8 days, the child experienced severe headache, accompanied by blurred vision and nausea. The head magnetic resonance imaging and 4-hour video electroencephalogram showed no abnormalities in the child. Cerebrospinal fluid pressure measured by lumbar puncture was 220 mmH 2O, and cerebrospinal fluid biochemistry and routine examination showed no abnormalities. After excluding intracranial infection, toxic encephalopathy, intracranial hemorrhage, and space-occupying lesions, it was considered that the increase of intracranial pressure was caused by minocycline. After discontinuing minocycline and administering symptomatic treatments such as mannitol, nonsteroidal anti-inflammatory drugs for 3 days, his headache was relieved. At 1-week and 1-month follow-up, no abnormal symptoms such as headache recurred in the child.
