Allergic pneumonia caused by mesalazine sustained-release granules
10.3760/cma.j.cn114015-20241010-00083
- VernacularTitle:美沙拉秦缓释颗粒致过敏性肺炎
- Author:
Tingting ZHANG
1
;
Xiaohong DANG
;
Caiqin LEI
;
Yan WANG
Author Information
1. 山西医科大学第一医院药学部，太原 030001
- Publication Type:Journal Article
- Keywords:
Lung diseases, interstitial;
Colitis, ulcerative;
Allergic pneumonia;
Mesalazine
- From:
Adverse Drug Reactions Journal
2025;27(7):438-440
- CountryChina
- Language:Chinese
-
Abstract:
A 57-year-old male patient with ulcerative colitis for more than 8 years was treated with mesalazine sustained-release granules 0.5 g thrice daily orally in the early stages of the disease, and the patient′s condition was improved. Chest CT scan showed no abnormalities in both lungs. The patient stopped taking the medication intermittently due to the remission of the condition over the course of 8 years, and due to the recurrence and worsening of symptoms, the dosage of mesalazine sustained-release granules was increased 3 times to 1 g orally, 4 times a day. At the first time, the patient experienced skin itching after taking increased dose of mesalazine for 2 days, which relieved after stopping the medication for 3 days. Afterwards, the dosage was reduced to 0.5 g thrice daily orally, and the patient′s skin itching did not recur. At the second time, the patient experienced skin itching on the trunk and limbs, chest tightness, and coughing 1 week after taking increased dose of mesalazine for 2 days, which relieved after stopping the medication for 2 days. At the third time, the patient experienced skin itching, chest tightness, and cough after taking increased dose of mesalazine for 1 day, which relieved after stopping the medication for 1 day. Laboratory tests showed no abnormalities in blood routine and C-reactive protein. High resolution CT scan of the chest revealed patchy ground glass opacities in both lungs, linear opacities in the lower lobes of both lungs, and cystic translucent opacities in the pleura of both lungs. Allergic pneumonia caused by mesalazine was considered.
