Clinicopathological analysis of 7 cases of indolent NK-cell lymphoproliferative dis-order of the gastrointestinal tract
10.13315/j.cnki.cjcep.2025.02.012
- VernacularTitle:胃肠道惰性NK细胞淋巴组织增殖性疾病7例临床病理分析
- Author:
Yanlin ZHANG
1
;
Jianlan XIE
1
;
Yuanyuan ZHENG
1
;
Xiaoge ZHOU
1
Author Information
1. 首都医科大学附属北京友谊医院病理科,北京 100050
- Publication Type:Journal Article
- Keywords:
lymphoproliferative disorder;
gastrointestinal tract;
indolent;
NK cells
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(2):209-214
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the clinical and pathological characteristics of indolent NK-cell lymphoprolifera-tive disorder(iNKLPD)of the gastrointestinal tract.Methods A retrospective analysis was conducted on the clinical pathological features,endoscopic findings,and immunophenotypes of 7 cases of iNKLPD.The study included in situ hybridization detection and literature review.Results The cohort comprised two males and five females,aged 28 to 54 years,with a median age of 40 years.The clinical manifestations varied,including acid reflux(two cases),nausea(three cases),stomach flatulence(five cases),and abdominal pain(one case).Lesions were observed at single sites in five cases and multiple sites in two cases.Involvement of the stomach,small intestine,and colon showed mucosal infiltration of small lymphocytes with abundant and clear cytoplasm,fine nuclear chromatin,and rare mitoses.Scat-tered eosinophils were observed in the background.Cases involving the gallbladder and bladder exhibited structural damage.The gallbladder lesion demonstrated cell with clear cytoplasm,condensed chromatin and prominent nucleoli.All cases were positive for CD3,CD56,CD7,TIA1 and Granzyme B,but negative for CD20,CD8 and CD5.Ki67 proliferation index from 10％to 50％.EBER in situ hybridization was negative in all cases.Follow-up periods ranged from 25 to 57 months(mean:38 months).All patients survived:four were asymptomatic,one had multiple-site in-volvement,and two experienced recurrence.Conclusion iNKLPD has an indolent clinical course and can involve multiple sites in the gastrointestinal tract and other organs.Differentiating it from invasive gastrointestinal lymphomas is critical to avoid misdiagnosis.
