Application of gene-editing technique in large experimental animals
10.3969/j.issn.1671-7856.2025.02.019
- VernacularTitle:基因编辑技术在实验大动物中的应用
- Author:
Chaonan LIU
1
;
Lihong YAN
;
Jing WANG
;
Yanhua SHEN
;
Mingming PAN
;
Zhengyu ZHOU
Author Information
1. 苏州大学苏州医学院实验动物中心,江苏苏州 215000
- Publication Type:Journal Article
- Keywords:
gene editing;
experimental animals;
model
- From:
Chinese Journal of Comparative Medicine
2025;35(2):175-180
- CountryChina
- Language:Chinese
-
Abstract:
Recent rapid developments in molecular biological techniques have allowed the use of gene editing,as a means of genome modification,for the establishment of experimental animal models,with high efficiency,accuracy,and flexibility.This article mainly summarizes the construction and application of the latest gene-editing techniques in animal models,including pigs,non-human primates and dogs.It provides a theoretical reference for the application and in-depth study of gene-editing techniques in large experimental animals,which may better simulate human diseases,and for further studies of the potential pathogenesis of biomedical and human complex diseases.
