One case of VV-ECMO treatment for dimethyl sulfate poisoning

VernacularTitle:VV-ECMO救治硫酸二甲酯中毒1例
Author: Dongquan ZHANG ¹ ; Maolin TONG ; Yuan YUAN ; Longfei GUO
Author Information

1. 甘肃省人民医院重症医学科，兰州　730000
Publication Type:Journal Article
Keywords: Dimethyl sulfate; Poisoning; Acute severe respiratory distress syndrome; Extracorporeal membrane oxygenation
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2025;43(11):862-864
CountryChina
Language:Chinese
Abstract: This paper analyzes the treatment process of a patient who developed severe acute respiratory distress syndrome (ARDS) following a chemical leak of dimethyl sulfate caused by factory operational error in February 2023, and explores the efficacy of extracorporeal membrane oxygenation (ECMO) in patient management. The patient developed severe respiratory symptoms five hours after chemical exposure and received sequential treatment with nasal high-flow oxygen therapy and invasive mechanical ventilation upon admission. When the oxygenation index dropped below 100 mmHg, veno-venous (VV) ECMO was initiated alongside 12-hour daily prone position ventilation to improve oxygenation and lung compliance. The patient recovered and was discharged following treatment. For patients with dimethyl sulfate poisoning complicated by severe ARDS, early implementation of VV-ECMO significantly improves treatment outcomes and prognosis.