Immune-related encephalitis induced by camrelizumab
10.3760/cma.j.cn114015-20240724-00629
- VernacularTitle:卡瑞利珠单抗致免疫相关性脑炎
- Author:
Li'na ZHANG
1
;
Hui FENG
1
;
Jinfeng LI
1
Author Information
1. 山东大学附属威海市立医院药剂科，威海 264299
- Publication Type:Journal Article
- Keywords:
Immune checkpoint inhibitors;
Immune-related encephalitis;
Camrelizumab
- From:
Adverse Drug Reactions Journal
2025;27(9):568-570
- CountryChina
- Language:Chinese
-
Abstract:
A 54-year-old male patient with lung adenocarcinoma received immunotherapy with camrelizumab (200 mg by intravenous infusion on day 1, with 21 days as one cycle) after operation. After 3 cycles of treatment, the patient developed fever, vomiting, urinary and fecal incontinence, unconsciousness, no response to verbal stimuli, and limb tremors. Cerebrospinal fluid test showed a positive Pandy test, with total protein of 1 173 mg/L and immunoglobulin G of 113 mg/L. Laboratory and imaging examinations excluded intracranial infection, brain metastasis, and metabolic encephalopathy, and the immune-related encephalitis due to camrelizumab was considered. Camrelizumab was stopped and methylprednisolone sodium succinate was given. Ten days later, the patient′s aforementioned symptoms disappeared.
