Changes in brain activity in patients with post-traumatic stress disorder two months after the traumatic event
10.3969/j.issn.1000-6729.2025.04.02
- VernacularTitle:创伤后应激障碍患者创伤事件2个月后大脑活动改变
- Author:
Luodong YANG
1
;
Haohao LI
1
;
Yao MENG
1
;
Min HU
1
;
Wenlong XING
1
;
Liang JIANG
1
;
Guiqing ZHANG
1
Author Information
1. 石河子大学第一附属医院临床心理科,新疆石河子 832008
- Publication Type:Journal Article
- Keywords:
post-traumatic stress disorder;
functional magnetic resonance imaging;
percent amplitude of fluctuation;
car accident
- From:
Chinese Mental Health Journal
2025;39(4):301-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore changes in brain activity in patients with post-traumatic stress disorder(PTSD).Methods:A total of 40 participants involved in car accidents were included,and functional magnetic reso-nance imaging(fMRI)scans were collected within one week.Anxiety,depression,and personality assessments were conducted with the Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),and Eysenck Person-ality Scale for Adult(EPQ).After two months,a second fMRI scan was conducted,and a PTSD diagnosis was made.Participants were divided into a trauma-exposed group(n=23)and a PTSD group(n=17)based on wheth-er they developed PTSD.Changes in brain functional activity between the trauma-exposed group and the PTSD group were compared using the percentage of amplitude fluctuation(perAF)method.Results:Compared to the trauma-exposed group,the PTSD group showed a decreased perAF value in the left hippocampus at 1 week,and de-creased perAF values in the right mid-cingulate gyrus and left postcentral gyrus at 2 months(P＜0.05).When comparing the PTSD group at different times,the perAF values in the left middle temporal gyrus and left medial su-perior frontal gyrus decreased at 2 months(P＜0.05).Correlation analysis revealed that PCL-5 scores were posi-tively correlated with EPQ Psychoticism(r=0.32,P=0.041),HAMA(r=0.35,P＜0.05),and HAMD(r=0.34,P＜0.05).Regression analysis found that higher scores of EPQ psychoticism(OR=11.79)and HAMA(OR=1.62)were risk factors for post-accident PTSD,while higher scores of EPQ extraversion(OR=0.32)were pro-tective factors.Conclusion:It suggests that patients with post-traumatic stress disorder may show decreased activity in the right middle cingulate cortex,left postcentral gyrus,left middle temporal gyrus,and left medial superior fron-tal gyrus within two months after the traumatic event.
