Analysis of risk factors for intolerance of valsartan with Sakubatrol in patients with heart failure

VernacularTitle:沙库巴曲缬沙坦在心衰患者使用中不耐受危险因素分析
Author: Jia WANG ¹ ; Lei WANG ; Binfa XU ; Feng LIU ; Xin WEN ; Min CHEN ; Yinsi GAO
Author Information

1. 安徽医科大学第三附属医院药学部,合肥 230061,安徽
Publication Type:Journal Article
Keywords: heart failure; sacubitril/valsartan; tol-erance; risk factor
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2025;30(2):232-237
CountryChina
Language:Chinese
Abstract: AIM:To investigate the risk factors for intolerance to sacubitril/valsartan in the treatment of heart failure.METHODS:A total of 124 heart fail-ure patients hospitalized in our hospital from May 2023 to May 2024 were collected.Logistic regres-sion analysis and nomogram analysis were used to identify the risk factors for drug tolerance.RE-SULTS:22 patients exhibited intolerance,with low blood pressure being the primary cause(P<0.05).Multivariate regression analysis found that patients with a low BMI(OR 95%CI 1.814(1.385-2.525))and those without concomitant right heart failure(OR 95%CI 4.998(1.552-17.301))were more likely to ex-perience drug intolerance.The model had a stable C-index of 0.923(95%CI=0.863-0.975).CONCLU-SION:Low BMI and absence of right heart failure are risk factors affecting the tolerance to sacubitril/valsartan,which has certain value for guiding clini-cal treatment.Large-sample clinical studies are still needed to confirm these findings.