Time-dependent diffusion MRI parameters for differentiating invasive breast cancer with ductal carcinoma in situ and simple invasive breast cancer
10.13929/j.issn.1672-8475.2025.04.006
- VernacularTitle:基于时间依赖弥散MRI参数鉴别浸润性乳腺癌伴导管原位癌与单纯浸润性乳腺癌
- Author:
Hao XU
1
;
Ao YANG
;
Yakun HE
;
Meining CHEN
;
Jieke LIU
;
Peng ZHOU
;
Heping DENG
Author Information
1. 四川省肿瘤临床医学研究中心,四川省肿瘤医院,四川省癌症防治中心,电子科技大学附属肿瘤医院影像科,四川成都 610000
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
carcinoma,ductal,breast;
magnetic resonance imaging,diffusion
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(4):255-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of time-dependent diffusion MRI(td-dMRI)parameters for differentiating invasive breast cancer(IBC)with ductal carcinoma in situ(DCIS)(IBC-DCIS)from simple IBC.Methods A total of 19 patients with IBC-DCIS(IBC-DCIS group)and 53 patients with simple IBC(IBC group)confirmed by surgery and postoperation pathology were retrospectively enrolled.Breast td-dMRI acquired with oscillating gradient spin-echo(OGSE)and pulsed gradient spin-echo(PGSE)sequences before operation were interpreted,and apparent diffusion coefficient(ADC)and microstructure parameters,including OGSE-ADC value,PGSE-ADC value,cellularity,cell diameter,intracellular volume fraction and extracellular diffusion coefficient were obtained and compared between groups.Receiver operating characteristic(ROC)curves of parameters being significantly different between groups were plotted,and the area under the curve(AUC)was calculated to evaluate the efficacy of these parameters for differentiating IBC-DCIS from IBC.Results Significant differences of OGSE-ADC value,PGSE-ADC value,cellularity,cell diameter,intracellular volume fraction and extracellular diffusion coefficient were found between groups(all P＜0.05).The AUC of the above parameters for differentiating IBC-DCIS from IBC was 0.81,0.79,0.78,0.68,0.77 and 0.81,respectively.Conclusion td-dMRI parameters could be used to noninvasively and effectively differentiate IBC-DCIS from simple IBC.
