Injection protocol of contrast agents based on individualized iodine delivery rate applicated in enhanced spectral CT scanning of colorectal cancer
10.13929/j.issn.1672-8475.2025.04.010
- VernacularTitle:个体化碘流率注射对比剂方案用于结直肠癌能谱CT增强扫描
- Author:
Jingyi ZHANG
1
;
Lei LIU
;
Yijun LIU
;
Shigeng WANG
;
Wei WEI
;
Zhiming MA
Author Information
1. 大连医科大学附属第一医院放射科,辽宁大连 116011
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
tomography,X-ray computed;
contrast media;
iodine flow rate;
prospective studies
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(4):279-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of contrast agent injection protocol based on individualized iodine delivery rate(IDR)applicated in enhanced spectral CT scanning of colorectal cancer.Methods Totally 131 colorectal cancer patients were prospectively collected and randomly divided into conventional group(group A,n=64,contrast agents were injected with routine method)and individualized group(group B,n=67,contrast agents were injected with individualized IDR method).Whole abdominal energy spectrum CT scanning was performed,and 70 keV images at arterial and venous phases(A70 keV)of group A and 40-70 keV images(interval 10 keV)at arterial and venous phases(B40-70 keV)of group B were reconstructed,and iodine-based material maps were reconstructed.Subjective and objective evaluation on quality of enhanced images were performed,lesions'normalized iodine concentration(NIC)were calculated,and the above indexes were compared between groups.Results Iodine intake in group B was lower than that in group A(P＜0.001).The subjective scores of B60 keV images at both arterial and venous phases were the highest,which were not different from those of A70 keV images(both P＞0.05).CT values,signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR)of superior mesenteric artery(SMA)and abdominal aorta on arterial B40-60 keV images were higher than those in arterial A70 keV images(all P＜0.05).CT values,SNR and CNR of superior mesenteric vein(SMV)on venous B40-50 keV,as well as CT values and CNR of SMV on venous B60 keV images were all higher than those on venous A70 keV images(all P＜0.05).No significant difference of lesions'NIC in arterial and venous phases was detected between groups(both P＞0.05).Conclusion Injection of contrast agents based on IDR combined with 60 keV single energy image for enhanced energy spectrum CT scanning of colorectal cancer could reduce the amount of contrast agents while do not affect imaging quality.
