Correlation between High-sensitivity C-reactive Protein-to-Lymphocyte Ratio and Severity of Coronary Heart Disease
10.11969/j.issn.1673-548X.2025.03.027
- VernacularTitle:超敏C反应蛋白与淋巴细胞比值和冠心病严重程度的相关性研究
- Author:
Wansh-en GAN
1
;
Aihua FEI
1
Author Information
1. 200092 上海交通大学医学院附属新华医院全科医学科
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
High-sensitivity C-reactive protein;
Lymphocytes;
Diagnosis;
Prediction
- From:
Journal of Medical Research
2025;54(3):147-151,197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between high-sensitivity C-reactive protein(hs-CRP)-to-lymphocyte ratio(CLR)and the severity of coronary heart disease,as well as the degree of coronary artery lesions.Methods A total of 603 patients who underwent coronary angiography in Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2022 to November 2023 were conducted on the retrospective analysis.All patients were divided into non-coronary heart disease group,stable an-gina pectoris(SAP)group,and acute coronary syndrome(ACS)group according to clinical classification.Basing on the Gensini score for coronary arteries,the extent of stenosis in patients'coronary arteries was classified into mild(0-31 points),moderate(31-61 points),and severe(≥61 points)groups.Differences in CLR and neutrophil-to-lymphocyte ratio(NLR)among groups were com-pared.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of CLR,NLR,and troponin Ⅰ for ACS.Spearman correlation analysis was used to evaluate the correlation between CLR,NLR and the degree of coronary stenosis.Results The CLR in the ACS group was higher than that in the SAP group,which was in turn higher than that in the non-coronary heart disease group,the differences were statistically significant(P＜0.05).The troponin Ⅰ and NLR in the ACS group were significantly higher than those in the SAP group(P＜0.05),but there was no statistical significance between the SAP group and non-coronary heart disease group(P＞0.05);the area under the curve(AUC)of CLR,NLR and troponin Ⅰ in predicting ACS were 0.787,0.730 and 0.837,re-spectively(P＜0.001).At the optimal cut-off value,the sensitivity and specificity of CLR were 75.5％and 71.6％.In the mild,moderate,and severe coronary lesion groups,with the degree of coronary stenosis worsened,levels of NLR and CLR increased correspond-ingly,and the differences were statistically significant(P＜0.05);Spearman correlation analysis demonstrated a positive correlation be-tween CLR,NLR and the degree of coronary stenosis in coronary heart disease patients(rCLR=0.308,rNLR=0.247,P＜0.001).Conclusion Levels of CLR have a positive correlation with the severity of disease and the degree of coronary artery lesions in coronary heart disease patients.Compared with NLR and troponin Ⅰ,it can better reflect the differences between stable-phase coronary heart dis-ease patients and non-coronary heart disease patients,and has a higher sensitivity in predicting ACS patients,providing clinical value for early diagnosis and condition evaluation in coronary heart disease patients.
