Study on characteristics and mechanism of Chinese herbs with fertility toxicity based on Traditional Chinese Medicine System Toxicology Database
10.3760/cma.j.cn114015-20240607-00423
- VernacularTitle:基于中药系统毒理学数据库的生育毒性中药特性及机制研究
- Author:
Yinglian CAI
1
;
Wenhua YANG
;
Min ZHANG
;
Zhongjian ZHENG
;
Senlin LIN
;
Yiqing LIN
;
Shuifang CHEN
;
Xuemei CHEN
Author Information
1. 厦门市中医院药学部，厦门市中药制剂研发与转化重点实验室，厦门 361006
- Publication Type:Journal Article
- Keywords:
Medicine, Chinese traditional;
Preconception injuries;
Genotoxicity;
Embryotoxicity;
Traditional Chinese Medicine System Toxicology Database
- From:
Adverse Drug Reactions Journal
2024;26(11):658-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics and mechanism of Chinese herbs with fertility toxicity.Methods:Chinese herbs with reproductive toxicity, developmental toxicity and genetic toxicity were retrieved from Traditional Chinese Medicine System Toxicology Database. The property, taste, meridian tropism, toxicity classification and performance, and the toxic component and action target of each medicinal material were collected and descriptive statistical analysis was performed.Results:A total of 55 kinds of Chinese herbs with fertility toxicity were screened out. They were mostly warm [20 (36.4%)] or cold [15 (27.3%)] in property, and mostly bitter and pungent in taste [bitter-pungent, bitter, and pungent accounted for 30.9% (17/55), 23.6% (13/55) and 18.2% (10/55)]. The channel tropisms were mainly liver, lung, spleen, and kidney [58.2% (32/55), 38.2% (21/55), 38.2% (21/55) and 34.5% (19/55)], and the main manifestations of its reproductive toxicity were reproductive function damage in males and females, abnormal embryonic growth and development and genetic/cytotoxicity, which might lead to reduced pregnancy rate, miscarriage, abnormal fetal growth and development, etc. There were 29 kinds of Chinese herbs with 35 known fertility toxic components. Among them, 30 toxic components had 11 known toxic targets. The more common toxic targets included thyroid hormone receptor beta, cytochrome P450 1A1, sex hormone-binding globulin and interleukin-1 beta.Conclusions:Chinese herbs with fertility toxicity are mostly warm or cold in property, and bitter and pungent in taste; their channel tropisms are mainly liver, lung, spleen and kidney; they mainly affect fertility and embryonic development by changing the body′s endocrine and interfering with sex hormone metabolism.
