Bioinformatics Analysis of NAT10 As A Potential Biomarker for Hepatocellular Carcinoma
10.11969/j.issn.1673-548X.2025.03.010
- VernacularTitle:NAT10作为肝癌潜在生物学标志物的生物信息学分析
- Author:
Dan WANG
1
;
Keyi JIANG
1
;
Songbo FU
1
Author Information
1. 150081 哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所;150081 国家卫生健康委病因流行病学重点实验室(哈尔滨医科大学)、黑龙江省普通高校病因流行病学重点实验室
- Publication Type:Journal Article
- Keywords:
NAT10;
Hepatocellular carcinoma;
Poor prognosis;
Biomarkers
- From:
Journal of Medical Research
2025;54(3):47-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance and potential mechanism of NAT10 in hepatocellular carcinoma.Meth-ods A total of 50 normal and 374 tumor samples were obtained based on The Cancer Genome Atlas(TCGA),and the data were pro-cessed by R 4.2.1.Results The expression of NAT10 in tumor samples was significantly higher than that in normal samples(P＜0.001).Compared with patients with low expression of NAT10,patients with high expression of NAT10had worse prognosis(P＜0.001).Logistic regression analysis showed that high NAT10 expression was associated with adverse clinical prognostic factors,and pa-tients with high NAT10 expression were more likely to progress to the advanced stage.Gene set enrichment analysis(GSEA)results showed that the genes related to heterobiotic metabolism,blood coagulation and fatty acid metabolism were differentially enriched in the samples with high expression of NAT10.The protein interaction analysis results showed that NAT10may interact with genes such as IGF2,SST,MUC2,CHGA,AGR2,etc.Conclusion NAT10 is highly expressed in hepatocellular carcinoma,and the expression level is cor-related with the clinical characteristics and survival rate of patients with hepatocellular carcinoma.NAT10may be a potential molecular bio-marker for hepatocellular carcinoma prognosis.
