Research status and ideas on protective effects of traditional Chinese medicine active monomers on tissues and organs based on Nrf2/GPX4 signaling pathway
- VernacularTitle:基于Nrf2/GPX4信号通路探讨中药活性单体对组织器官保护作用的研究现状与思路
- Author:
Wu-zhen HUANG
1
;
Si-ning CHEN
;
Zhan-hua LI
Author Information
- Publication Type:Journal Article
- Keywords: Nrf2/GPX4 signaling pathway; ferroptosis; tradi-tional Chinese medicine active monomers; Exploration of mecha-nism of action; tissue and organ damage; protective effect
- From: Chinese Pharmacological Bulletin 2025;41(4):613-620
- CountryChina
- Language:Chinese
- Abstract: Ferroptosis is a cell death pattern associated with the regulation of the Nrf2/GPX4 signaling pathway.Activating the Nrf2/GPX4 signaling pathway can regulate the expression of genes and proteins related to oxidative stress,alleviate stress damage,and inhibit cell ferroptosis.At present,research on the intervention of traditional Chinese medicine in ferroptosis has made certain progress.Through literature research,it can be found that some traditional Chinese medicine active monomers can activate the Nrf2/GPX4 signaling pathway to inhibit ferrop-tosis,play a protective role in tissues and organs,and have ther-apeutic potential in various diseases.Some traditional Chinese medicine active monomers exhibit characteristics of multi organ protective effects and bidirectional regulation.This article discus-ses the relevant research on the inhibition of ferroptosis by acti-vating the Nrf2/GPX4 signaling pathway with traditional Chinese medicine active monomers,and proposes suggestions to provide reference and ideas for further basic and applied research.
