Research progress on the resistance mechanism of anti-angiogenesis targeted drugs in the treatment of colorectal cancer
10.12092/j.issn.1009-2501.2025.02.005
- VernacularTitle:抗血管生成靶向药物在治疗结直肠癌的耐药机制研究进展
- Author:
Haitao JIANG
1
;
Yangxian XU
1
Author Information
1. 上海中医药大学附属龙华医院普外二科,上海 200032
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
anti-angiogenesis;
mechanism of drug resistance;
targeted therapy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(2):193-199
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC)is one of the most common malignancies worldwide,although anti-angiogenic targeted agents such as bevacizum-ab have shown significant efficacy in the treatment of metastatic CRC,however,the emergence of drug resistance is still a key obstacle affecting the suc-cess rate of treatment and survival of patients.This article reviews the progress of anti-angiogenesis targeted drugs in the treatment of CRC,the mecha-nism of drug resistance and how to solve the prob-lem of drug resistance.
