Liver injury induced by Panlongqi tablets (盘龙七片)
10.3760/cma.j.cn114015-20231007-00720
- VernacularTitle:盘龙七片致肝损伤
- Author:
Zhiyu XU
1
;
Zhiheng DONG
1
;
Aiwu ZHANG
1
Author Information
1. 内蒙古医科大学附属医院药学部，呼和浩特 010050
- Publication Type:Journal Article
- Keywords:
Aconitine;
Chemical and drug induced liver injury;
Traditional Chinese medicine;
Panlongqi tablets
- From:
Adverse Drug Reactions Journal
2024;26(8):504-506
- CountryChina
- Language:Chinese
-
Abstract:
A 67-year-old female patient was treated with oral 4 Panlongqi tablets thrice daily for strain of lumbar muscles. The patient developed nausea and poor appetite after 3 days of administration, followed by discharging strong brown urine and clay-colored stools. After 15 days of using the drug, she developed yellow staining of the skin and sclera, and itching appeared throughout the body. Laboratory tests showed alanine aminotransferase (ALT) 304 U/L, aspartate aminotransferase (AST) 168 U/L, alkaline phosphatase (ALP) 463.6 U/L, gamma glutamyltransferase (GGT) 1 332.3 U/L, total bilirubin (TBil) 110.5 μmol/L, and direct bilirubin (DBil) 92.3 μmol/L. After excluding viral hepatitis and biliary obstruction, drug-induced liver injury was diagnosed. Panlongqi tablets were stopped, and magnesium isoglycyrrhizinate, polyene phosphatidylcholine, ursodeoxycholic acid, and methylprednisolone were given. The patient′s discomfort symptoms were gradually eased and liver function was gradually improved. After 14 days of treatments, percutaneous liver biopsy under color doppler ultrasound was performed, and she was diagnosed as acute cholestatic hepatitis with mild fibrosis in the portal area, possibly caused by drug. After 16 days of treatments, the medication was switched to oral hepatoprotective drugs for 2 weeks. One week after stopping treatments, the patient had no discomfort and the color of skin and sclera was normal. The liver function was normal, showing ALT 31 U/L, AST 25 U/L, ALP 83.9 U/L, GGT 37.0 U/L, TBil 19.8 μmol/L, and DBil 7.3 μmol/L.
