Norethindrone-induced acute pulmonary embolism with cardiac arrest
10.3760/cma.j.cn114015-20240122-00056
- VernacularTitle:炔诺酮致急性肺栓塞并心脏停搏
- Author:
Wenbin GUO
1
;
Tingting WANG
1
;
Qingyue LIU
1
;
Xinhong WEI
1
Author Information
1. 山东第一医科大学附属聊城市第二人民医院重症医学科，临清 252600
- Publication Type:Journal Article
- Keywords:
Endometrial hyperplasia;
Pulmonary embolism;
Norethindrone;
Heart arrest;
Extracorporeal membrane oxygenation
- From:
Adverse Drug Reactions Journal
2024;26(10):638-640
- CountryChina
- Language:Chinese
-
Abstract:
A 44-year-old female patient was treated with norethisterone 5 mg once every 8 hours due to atypical hyperplasia of endometrium. One month later, the patient developed asthma with cyanosis, and sudden cardiac arrest later. According to the results of electrocardiogram and echocardiogram examination, acute pulmonary embolism with cardiac arrest was diagnosed. Cardiac resuscitation was immediately implemented, and thrombolysis and anticoagulation therapies were performed, accompanied by veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for life support. After 5 minutes of thrombolytic therapy, the patient′s heart beat and blood pressure gradually recovered. The results of pulmonary artery CT angiography supported the diagnosis of acute pulmonary embolism and effectiveness of thrombolysis. After 31 hours of thrombolytic therapy, the patient has stabilized vital signs and VA-ECMO was removed. After 47 hours of thrombolytic therapy, the patient′s consciousness fully recovered, the tracheal tube was removed, and anticoagulant therapy was continued. After 11 days of thrombolytic therapy, the echocardiography was re-performed, showing normal pulmonary artery pressure, and the exercise tolerance was checked to be good. At 1 month of follow-up, the cardiac function and structure were normal on echocardiography, no thrombus was found on lower limb vascular ultrasound.
