Alternative Splicing in Embryo Implantation
10.1097/FM9.0000000000000272
- VernacularTitle:Alternative Splicing in Embryo Implantation
- Author:
Luping YU
1
;
Sijing ZHU
;
Haili BAO
;
Shuangbo KONG
Author Information
1. Reproductive Medicine Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China
- Publication Type:Journal Article
- Keywords:
Embryo implantation;
EMT/MET;
Spliceosome;
Splicing
- From:
Maternal-Fetal Medicine
2025;07(2):85-94
- CountryChina
- Language:English
-
Abstract:
Alternative splicing (AS) is a crucial process that produces functionally distinct proteins from a single gene, depending on the developmental or physiological state of cells in multicellular organisms. It plays a significant role in cellular proliferation, survival, and differentiation, including embryonic development, spermatogenesis, and a broad spectrum of diseases. However, the precise involvement of AS in embryo implantation is still unclear. In this review, we summarize the potential roles of AS in regulating mesenchymal-epithelial transitions during embryo implantation, specifically in epithelium regeneration and decidualization initiation via the mesenchymal-epithelial transformation process. Overall, this review emphasizes the impact of AS and splicing variants on embryo implantation and offers novel insights into the potential application of alternative splicing in the treatment of female infertility.
