Pseudo-elevation of serum creatinine due to abemaciclib in a patient with bone metastasis of breast cancer
10.3760/cma.j.cn114015-20231023-00751
- VernacularTitle:阿贝西利致乳腺癌骨转移患者假性血肌酐升高
- Author:
Minting CHEN
1
;
Yan LIU
;
Jie MA
;
Ke ZHENG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院内科，北京 100730
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Neoplasm metastasis;
Pseudo-elevation of serum creatinine;
Abemaciclib
- From:
Adverse Drug Reactions Journal
2024;26(9):563-565
- CountryChina
- Language:Chinese
-
Abstract:
A 53-year-old female patient with bone metastasis of breast cancer received targeted drugs (abemaciclib 150 mg orally twice daily, exemestane 25 mg orally once daily), zoledronic acid (4 mg IV infusion once per month), traditional Chinese medicine, and non-steroidal anti-inflammatory drugs. After 2 months, her serum creatinine (Scr) increased from 84 μmol/L before treatment to 156 μmol/L. Due to renal tissue puncture biopsy, the patient missed taking abemaciclib for 1 day. The laboratory tests next day showed that her Scr decreased from 151 μmol/L to 123 μmol/L. Comparing the estimated glomerular filtration rate calculated using serum cystatin C with that calculated using Scr, combined with the pathological examination results of renal biopsy tissue, the patient′s renal injury caused by other drugs could be ruled out, and the possibility of pseudo-elevation of Scr caused by abemaciclib was considered.
