Research progress of interaction between RNA binding protein HuR and non-coding RNA in diseases
- VernacularTitle:RNA结合蛋白HuR与非编码RNA相互作用在疾病中的研究进展
- Author:
Yong HUANG
1
;
Xiao-man YUAN
1
;
Ling-wei LIU
1
;
Song-pei LI
1
Author Information
- Publication Type:Journal Article
- Keywords: human antigen R; non-coding RNA; miRNA; ln-cRNA; circRNA; post-transcriptional regulation
- From: Chinese Pharmacological Bulletin 2025;41(4):601-605
- CountryChina
- Language:Chinese
- Abstract: RNA-binding protein human antigen R(HuR)is a protein product of the embryonic lethal abnormal vision gene(ELAVL).It is widely expressed in human cells and primarily regulates mRNA stability through post-transcriptional mecha-nisms,particularly by binding to AU-enriched elements(AR-Es).Recent studies have indicated that HuR interacts with non-coding RNAs to participate in the regulation of gene expression,including long non-coding RNAs,circular RNAs,microRNAs,and vault RNAs.The interactions between HuR and these ncR-NAs play a crucial role in the occurrence and development of va-rious diseases,including tumors.Since there are already reviews summarizing the research on tumors,this review mainly focuses on summarizing the role of HuR-ncRNA interactions in diseases other than tumors.
