Molecular mechanisms and prospects for disease treatment of ciliogenesis and autophagy
- VernacularTitle:纤毛生成与自噬的分子机制探究及疾病治疗前景
- Author:
Hao-liang HU
1
;
Jin WANG
;
Jia-yan LIU
;
Shi-fang HUANG
;
Yu-ting LI
;
Zhe CHEN
;
Lin-xi CHEN
Author Information
- Publication Type:Journal Article
- Keywords: cilia; autophagy; ciliogenesis; cilia-related disea-ses; small molecule inhibitors; selective autophagy
- From: Chinese Pharmacological Bulletin 2025;41(4):631-637
- CountryChina
- Language:Chinese
- Abstract: Cilia,as cellular sensory organelles,actively partici-pate in and regulate cellular processes such as autophagy and metabolic breakdown during their generation and transportation.Autophagy,on the other hand,is a cell self-protection mecha-nism that maintains cellular homeostasis by clearing aggregates and damaged organelles.Combining recent research findings,this review comprehensively elucidates the bidirectional crosstalk between primary cilia and autophagy.Specifically,it highlights the crucial role of cilia-dependent signaling pathways in activa-ting cellular autophagy and how autophagy regulates cilia genera-tion and length by degrading specific ciliary proteins.Moreover,the dysregulation of primary cilia and autophagy is closely asso-ciated with the clinical manifestations and pathogenesis of vari-ous ciliopathy-related diseases such as polycystic kidney disease and tuberous sclerosis.In terms of pharmacotherapy,this review provides a comprehensive and in-depth overview of small mole-cule inhibitors targeting ciliogenesis,including cytoskeletal drugs and Hedgehog signaling pathway inhibitors.Despite the current limitations in clinical use,these drugs lay the groundw-ork for developing highly specific targeted small molecule inhibi-tors of ciliogenesis and for the treatment of ciliopathies and canc-ers.By systematically discussing ciliogenesis,autophagy,disea-ses and drugs,this review offers new insights for further elucida-ting the crosstalk between ciliogenesis and autophagy,exploring their pathological mechanisms in disease development,and de-veloping therapeutic strategies in the future.
