Research status of lactate regulation of chronic liver disease
10.13699/j.cnki.1001-6821.2025.01.023
- VernacularTitle:乳酸调控慢性肝病的研究现状
- Author:
Lei WANG
1
;
Jia-xin BAI
;
Yu-ling ZHUANG
;
Jia-hui WANG
;
Tie-jian ZHAO
;
Na HUANG
;
Yang ZHENG
;
Hua-ye XIAO
Author Information
1. 广西中医药大学,研究生学院,广西壮族自治区南宁 530222;广西中医药大学,赛恩斯 新医药学院,广西壮族自治区南宁 530222
- Publication Type:Journal Article
- Keywords:
lactate;
chronic liver disease;
immune response;
oxidative stress;
energy metabolism;
mitochondrial dynamics
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(1):111-115
- CountryChina
- Language:Chinese
-
Abstract:
Excessive fat accumulation,viral infections and sustained inflammatory responses caused by non-alcoholic and alcoholic factors can contribute to liver inflammation,fibrosis and carcinogenesis,promoting the development of chronic liver disease.Gaining an in-depth understanding of the etiologic factors and underlying mechanisms that lead to chronic liver disease can help identify potential therapeutic targets for targeted therapy.Lactate,as an important substance in hepatic metabolism,has been found to be involved in the process of chronic liver disease through various pathways,and this review will provide a useful reference for the prevention and treatment of chronic liver disease.
