Acute kidney failure induced by henagliflozin
10.3760/cma.j.cn114015-20240206-00089
- VernacularTitle:恒格列净致急性肾衰竭
- Author:
Zhen YE
1
;
Xin LYU
;
Xiaodan CAI
Author Information
1. 江苏省人民医院宿迁医院药学部，宿迁 223813
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Acute kidney injury;
Sodium-glucose transporters 2 inhbitors;
Henagliflozin
- From:
Adverse Drug Reactions Journal
2024;26(10):631-633
- CountryChina
- Language:Chinese
-
Abstract:
A 45-year-old male patient with type 2 diabetes mellitus was additionally treated with henagliflozin (10 mg, once daily), enalapril, fenofibrate, finerenone, celecoxib, eperisone and mecobalamin due to poor glycemic control, hypertension, hyperlipidemia and other conditions at previous therapy of insulin aspart 30 and acarbose. Before the additional medication, the patient′s serum creatinine (Scr) and blood urea nitrogen (BUN) were normal., Later, the patient discontinued celecoxib, finerenone, and fenofibrate by himself as relevant symptoms were improved successively. On the 36th day of medication, the patient experienced paroxysmal pain in the lumbar region, which gradually worsened. Then the patient stopped using henagliflozin by himself 2 days later while the other medications remained. The next day, laboratory tests indicated Scr 180 μmol/L and BUN 9.6 mmol/L, and acute kidney failure was diagnosed. Analgesic, antispasmodic and glucocorticoid pulse therapy was administered, and the patient′s lumbar pain was gradually improved. On the 6th day of discontinuing henagliflozin, Scr was 142 μmol/L and BUN was 9.4 mmol/L; on the 9th day, Scr was 113 μmol/L and BUN was 9.1 mmol/L; approximately 3 months after drug discontinuation, Scr was 66 μmol/L and BUN was 6.0 mmol/L.
