Research progress on population load and hepatotoxicity of glyphosate
10.3760/cma.j.cn121094-20240422-00174
- VernacularTitle:草甘膦人群负荷及肝脏毒性的研究进展
- Author:
Jie LU
1
;
Boshen WANG
;
Baoli ZHU
Author Information
1. 东南大学环境医学工程教育部重点实验室，南京 210009
- Publication Type:Journal Article
- Keywords:
Poisoning;
Glyphosate;
Hepatotoxicity;
Oxidative stress;
Mitochondrial dysfunction;
Inflammation
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2025;43(9):713-720
- CountryChina
- Language:Chinese
-
Abstract:
Glyphosate is an organophosphorus herbicide with a large global production volume and wide application. It is commonly present in the environment and has a relatively long residual period. Its long-term toxicity, carcinogenic potential and other health effects deserve attention and further research. Glyphosate exposure has toxic effects on a variety of organs, including but not limited to hepatotoxicity, reproductive toxicity, neurotoxicity, etc., and is associated with the occurrence and development of different types of cancer. This article summarizes the physicochemical properties of glyphosate, its usage and pollution status in China, sorts out and summarizes its population load situation, and focuses on discussing the hepatotoxic effects of glyphosate under various exposure scenarios, including the acute poisoning situation and the progress of long-term low-dose exposure in the general population, and long-term high dose exposure condition in the occupational population. The hepatotoxic effects of glyphosate on mammals, fish, and organs and cells in vitro experiments were deeply analyzed. The possible toxicological mechanism of glyphosate hepatotoxicity was analyzed from oxidative stress, mitochondrial dysfunction, inflammation and other aspects, aiming to explore the effects of glyphosate exposure on liver health and provide a reference for scientific guidance on the rational use of glyphosate.
