First Trimester Preeclampsia Screening and Prevention: Perspective in Chinese Mainland
10.1097/FM9.0000000000000215
- VernacularTitle:First Trimester Preeclampsia Screening and Prevention: Perspective in Chinese Mainland
- Author:
Jiao LIU
1
;
Yunyu CHEN
1
;
Tai Sin TING
1
;
Long NGUYEN-HOANG
1
;
Kunping LI
1
;
Jing LIN
1
;
Xiaohong LU
1
;
Poon Liona C.
1
Author Information
1. Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China
- Publication Type:Journal Article
- Keywords:
Preeclampsia;
Chinese population;
First trimester;
Screening;
Prevention
- From:
Maternal-Fetal Medicine
2024;06(2):84-91
- CountryChina
- Language:English
-
Abstract:
Preeclampsia (PE), a multisystem disorder in pregnancy, is one of the leading causes of perinatal morbidity and mortality that poses financial and physical burdens worldwide. Preterm PE with delivery at <37 weeks of gestation is associated with a higher risk of adverse maternal and perinatal outcomes than term PE with delivery at ≥37 weeks of gestation. A myriad of first trimester screening models have been developed to identifying women at risk of preterm PE. In fact, the Fetal Medicine Foundation (FMF) first trimester prediction model has undergone successful internal and external validation. The FMF triple test enables the estimation of patient-specific risks, using Bayes theorem to combine maternal characteristics and medical history together with measurements of mean arterial pressure, uterine artery pulsatility index, and serum placental growth factor. Establishing a quality control process for regular monitoring and to ensure data standardization, reliability, and accuracy is key to maintaining optimal screening performance. The rate of preterm PE can be reduced by 62% by using the FMF prediction model, followed by the administration of low-dose aspirin. Recent evidence has also demonstrated that metformin has the potential for preventing PE in patients at high-risk of the disorder. In this article, we will summarize the existing literature on the different screening methods, different components of risk assessment, therapeutic interventions, and clinical implementation of the first trimester screening and prevention program for PE with specific considerations for Chinese mainland.
