Subacute toxicity study of triethylenediammonium perchlorate ammonium complex salt in rats
10.3760/cma.j.cn121094-20241010-00461
- VernacularTitle:三乙烯二铵高氯酸铵复盐的大鼠亚急性毒性研究
- Author:
Hui DENG
1
;
Hongni LIU
;
Huan LI
;
Ting GAO
;
Cunzhi LI
;
Xiaoqiang LYU
;
Zhiyong LIU
;
Junhong GAO
Author Information
1. 兵器工业卫生研究所毒理技术研究中心，西安 710065
- Publication Type:Journal Article
- Keywords:
Rats;
Toxicity tests;
Triethylenediammonium perchlorate ammonium complex salt (DAP-4);
Subacute toxicity;
Safe dosage
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2025;43(9):693-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the subacute toxicity and target organs of triethylenediammonium perchlorate ammonium complex salt (DAP-4) .Methods:In August 2024, 40 SPF-grade SD rats were selected, with 10 rats in each group, half male and half female. There were 45, 140, and 420 mg/kg DAP-4 groups and a control group. Rats in each dose DAP-4 group were orally administered the corresponding amount of DAP-4 solution, while the control group was given the same dose of 1% sodium carboxymethyl cellulose. SD rats were given intragastric administration once a day for 28 consecutive days. The behaviors, histopathological changes, and blood physiological and biochemical indicators of rats were detected at the corresponding time points respectively. One-way analysis of variance was used for the comparison of quantitative data between groups.Results:Compared with the control group, the body weight, food intake and food utilization rate of female and male rats in the 420 mg/kg DAP-4 group were significantly decreased ( P<0.05), while no abnormalities were observed in the other dose groups. Compared with the control group, the white blood cell count of female rats in the 420 mg/kg DAP-4 group decreased, while the hemoglobin and hematocrit decreased and the total serum protein increased of male rats ( P<0.05). Compared with the control group, fibrinogen was increased in both female and male rats in the 420 mg/kg DAP-4 group, and the thrombin time of female rats was shortened ( P<0.05). In each dose group, the livers of female and male rats showed varying degrees of vacuolar degeneration, and the renal tubules of female rats were swollen. Conclusion:420 mg/kg DAP-4 can cause damage to the liver and kidney of rats, and the maximal no effect level of DAP-4 for rats is 140 mg/kg.
