Hyperthyroidism caused by semaglutide injection
10.3760/cma.j.cn114015-20231115-00807
- VernacularTitle:司美格鲁肽注射液致甲状腺功能亢进
- Author:
Lingyan GAO
1
;
Lihua GAO
;
Hua LIU
Author Information
1. 航天中心医院药剂科，北京 100049
- Publication Type:Journal Article
- Keywords:
Hyperthyroidism;
Arrhythmia, sinus;
Weight lose;
Semaglutide
- From:
Adverse Drug Reactions Journal
2024;26(5):315-317
- CountryChina
- Language:Chinese
-
Abstract:
A 31-year-old woman received semaglutide injection subcutaneously for weight loss. Three months later, the electrocardiogram showed sinus tachycardia, and the laboratory tests showed triiodothyronine (T 3) 2.75 nmol/L, thyroxine (T 4) 199.86 nmol/L, free triiodothyronine (FT 3) 11.31 pmol/L, free thyroxine (FT 4) 46.63 pmol/L, thyroid-stimulating hormone (TSH)<0.005 mU/L. Considering the sinus tachycardia and hyperthyroidism caused by semaglutide injection, the drug was discontinued, and methimazole 10 mg orally, twice daily and metoprolol 25 mg orally twice daily were given. After treatment for more than 1 month, the electrocardiogram of the patient was normal, and the thyroid function examination showed T 3 1.79 nmol/L, T 4 127.33 nmol/L, FT 3 4.94 pmol/L, FT 4 15.87 pmol/L, and TSH<0.005 mU/L. However, there were elevated liver enzymes, showing alanine aminotransferase 327 U/L, aspartate aminotransferase 148 U/L, and γ-glutamyl transpeptidase 123.4 U/L. Then, methimazole and metoprolol were stopped, and silibinin 140 mg orally thrice daily combined with bicyclol 50 mg thrice daily were given. More than 1 month after treatments, the patient′s thyroid function and liver function were normal, and silibinin and bicyclol were stopped. After that, the thyroid function, liver function and electrocardiogram were all normal in repeated examinations.
