Erythema multiforme-like drug eruption induced by linagliptin
10.3760/cma.j.cn114015-20240115-00028
- VernacularTitle:利格列汀致多形性红斑药疹
- Author:
Shidi CHEN
1
;
Ke JIA
;
Fang LIU
Author Information
1. 北京市海淀医院药剂科，北京 100080
- Publication Type:Journal Article
- Keywords:
Drug eruption;
Erythema multiforme;
Linagliptin;
Hypoglycemic drugs
- From:
Adverse Drug Reactions Journal
2024;26(10):633-635
- CountryChina
- Language:Chinese
-
Abstract:
A 62-year-old male patient received antiplatelet aggregation, lipid-lowering and hypoglycemic therapy due to cerebral infarction complicated with hypertension and diabetes.After 9 days, linagliptin (5 mg orally once daily) and ertugliflozin (5 mg orally once daily) were added due to the poor blood glucose control. The next day after taking the 2 drugs, he developed a scattered rash on the chest, which gradually worsened. A large number of circular target-like erythema appeared on the trunk andproximal limbs, accompanied by pain but no obvious itching. On the 8th day after taking the 2 drugs, the dermatologist consulted and the patient was diagnosed with drug-induced rash, which was considered to be induced by linagliptin. Then linagliptin and ertugliflozin were discontinued. The patient received intravenous infusion of methylprednisolone 40 mg once daily, along with symptomatic treatments such as antihistamines. On the 4th day of treatments, the rash on his chest and back merged into a large area, accompanied by significant flaking; the dosage of methylprednisolone was increased to 80 mg by intravenous injection once daily. On the 7th day of treatments, the rash slightly subsided, and the dosage of methylprednisolone was reduced to 60 mg by intravenous injection once daily. On the 10th day of treatments, the rash was improved significantly. Corticosteroids and antihistamines were gradually discontinued. At a two-week follow-up, the patient′s rash disappeared.
