Twelve cases of occupational acute 2- (2-thiophenyl) scopolamine glycolate poisoning
10.3760/cma.j.cn121094-20240508-00205
- VernacularTitle:职业性急性2-（2-噻吩基）乙醇酸东莨菪酯中毒12例
- Author:
Yugui HAO
1
;
Minghui WANG
;
Jilai QU
;
Xuechuang ZHU
;
Jian LIU
;
Xinxiao WANG
Author Information
1. 枣庄市立医院急救中心，枣庄 277101
- Publication Type:Journal Article
- Keywords:
Occupational diseases;
2- (2-thiophenyl) scopolamine glycolate;
Poisoning;
Tiotropium bromide
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2025;43(6):453-455
- CountryChina
- Language:Chinese
-
Abstract:
2- (2-thiophenyl) scopolamine glycolate is produced through an ester exchange reaction between scopine and methyl 2, 2-dithienylglycolate, and is used to synthesize tiotropium bromide. In this paper, the treatment process of 12 patients with acute 2- (2-thiophenyl) scopolamine glycolate poisoning was reviewed and their clinical data were analyzed. After a large amount of 2- (2-thiophenyl) scopolamine glycolate was absorbed through the respiratory tract, the poisoning patients presented with central nervous system injury as the main clinical manifestations, accompanied by symptoms such as blurred vision and irritability. After fluid replacement, ovulation induction and symptomatic supportive treatment, all patients improved and were discharged. The patients were followed up. After 6 months, only 3 patients had residual headache and dizziness. It is indicated that early intervention for acute 2- (2-thiophenyl) scopolamine glycolate poisoning has a good prognosis. Meanwhile, occupational protection should be strengthened to prevent the occurrence of poisoning.
