Expression of Key Steroidogenic Enzymes in Human Placenta and Associated Adverse Pregnancy Outcomes
10.1097/FM9.0000000000000167
- VernacularTitle:Expression of Key Steroidogenic Enzymes in Human Placenta and Associated Adverse Pregnancy Outcomes
- Author:
Jiasong CAO
1
;
Yixin WANG
;
Shuqi WANG
;
Yongmei SHEN
;
Wen LI
;
Zhuo WEI
;
Shanshan LI
;
Qimei LIN
;
Ying CHANG
Author Information
1. Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin Central Hospital of Gynecology Obstetrics and Nankai University Affiliated Hospital of Obstetrics and Gynecology, Tianjin 300100, China
- Publication Type:Journal Article
- Keywords:
Placenta;
Steroidogenic enzymes;
Maternal-fetal outcomes;
Cytochrome P450;
Hydroxysteroid dehydrogenase
- From:
Maternal-Fetal Medicine
2023;05(3):163-172
- CountryChina
- Language:English
-
Abstract:
Steroid hormones, including progestagens, estrogens, androgens, corticosteroids, and their precursor cholesterol, perform essential functions in the successful establishment and maintenance of pregnancy and normal fetal development. As the core endocrine organ at the prenatal stage, the human placenta is involved in the biosynthesis, metabolism, and delivery of steroid hormones. Steroidogenic pathways are tightly regulated by placenta-intrinsic cytochrome P450 and hydroxysteroid dehydrogenase. However, the relationship between placental steroidogenic enzyme expression and adverse pregnancy outcomes is controversial. In this review, we summarize the possible upstream regulatory mechanisms of placental steroidogenic enzymes in physiologic and pathophysiologic states. We also describe the human placental barrier model and examine the potential of single-cell sequencing for evaluating the primary functions and cellular origin of steroidogenic enzymes. Finally, we examine the existing evidence for the association between placental steroidogenic enzyme dysregulation and adverse pregnancy outcomes.
