Acute liver injury induced by levonorgestrel dispersible tablets in a patient with chronic hepatitis B
10.3760/cma.j.cn114015-20230926-00712
- VernacularTitle:左炔诺孕酮分散片致慢性乙型肝炎患者急性肝损伤
- Author:
Bin WANG
1
;
Jingjing FU
;
Zhenping FAN
Author Information
1. 解放军总医院第五医学中心保健五科，北京 100039
- Publication Type:Journal Article
- Keywords:
Levonorgestrel;
Chemical and drug induced liver injury;
Hepatitis B;
Contraceptive agents;
Medication errors
- From:
Adverse Drug Reactions Journal
2024;26(3):184-185
- CountryChina
- Language:Chinese
-
Abstract:
A 37-year-old female patient with chronic hepatitis B was treated with levonorgestrel dispersible tablets (1.5 mg daily, 21 days of medication and 7 days off in a month) due to menstrual disorder. Three months later, the patient developed nausea, vomiting, poor appetite, and jaundice successively. Laboratory tests showed alanine aminotransferase 93 U/L, aspartate aminotransferase 68 U/L, γ-glutamyltransferase 100 U/L, total bilirubin 206.1 μmol/L, and direct bilirubin 138.9 μmol/L. After excluding chronic hepatitis B reactivation and other hepatotropic virus infections by laboratory indicators, the liver injury was considered to be related to levonorgestrel. Levonorgestrel was stopped, liver protective and symptomatic treatments were given, the patient′s symptoms gradually disappeared, and liver function returned to normal after 2 months. The pathological examination result of liver puncture supported the diagnosis of chronic hepatitis B complicated with acute drug-induced liver injury.
