Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth
10.1097/FM9.0000000000000199
- VernacularTitle:Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth
- Author:
Yongmei SHEN
1
;
Yaqi LI
;
Jiasong CAO
;
Wen LI
;
Qimei LIN
;
Jianxi WANG
;
Zhuo WEI
;
Ying CHANG
Author Information
1. Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin Central Hospital of Gynecology Obstetrics and NanKai University Maternity Hospital, Tianjin 300100, China
- Publication Type:Journal Article
- Keywords:
Gonadal steroid hormones;
Immunity tolerance;
Inflammation;
Premature birth
- From:
Maternal-Fetal Medicine
2023;05(4):229-237
- CountryChina
- Language:English
-
Abstract:
In 2019, preterm births (PTB) accounted for approximately 0.66 million deaths globally. PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns. Long-term studies associated several factors, including disruption of immune tolerance and inflammation, with PTB. However, the pathogenesis of PTB remains unclear. Gonadal steroid hormones are critical for pregnancy maintenance and regulation of immune and inflammatory responses. However, it is not clear how unbalanced gonadal steroid hormones, such as imbalanced estrogen/androgen or estrogen/progesterone contribute to PTB. In this review, we discuss how gonadal steroid hormones mediate dysfunction in immune tolerance and inflammatory responses, which are known to promote the occurrence of PTB, and provide insight into PTB prediction.
