Severe liver injury caused by Hehe pills (和合丸)
10.3760/cma.j.cn114015-20230425-00307
- VernacularTitle:和合丸致重度肝损伤
- Author:
Kongli FAN
1
;
Guangwei FU
;
Xisheng SANG
Author Information
1. 焦作市第二人民医院消化科，焦作 454000
- Publication Type:Journal Article
- Keywords:
Drugs, Chinese herbal;
Drug-induced liver injury;
Hehe pills
- From:
Adverse Drug Reactions Journal
2024;26(4):246-248
- CountryChina
- Language:Chinese
-
Abstract:
A 64-year-old female patient with bilateral knee joint pain received Hehe pills 10 g twice daily by herself. After 2 months of treatment, she stopped taking the medicine. On the 10th day after discontinuation of medication, yellowish skin, mucosa, and sclera appeared. Laboratory tests showed alanine aminotransferase 274 U/L, aspartate aminotransferase 274 U/L, alkaline phosphatase 713 U/L, total bilirubin 412.7 mmol/L, direct bilirubin 216.2 mmol/L. Severe liver injury caused by Hehe pills was considered. Symptomatic and supportive treatments including liver protection and jaundice reduction, and bilirubin adsorption were given. One month later, the yellowish skin, mucosa, and sclera in the patient were significantly improved, and 2 months later, liver function returned to normal. The patient′s liver injury was most likely related to the Aconiti Kusnezoffii Radix, Aconiti Radix, Olibanum, and Myrrha contained in Hehe pills.
