Desloratadine citrate-induced rash and angioneurotic edema
10.3760/cma.j.cn114015-20231016-00734
- VernacularTitle:枸地氯雷他定致皮疹和血管神经性水肿
- Author:
Ningning GUO
1
;
Gaofei FANG
Author Information
1. 烟台市莱阳中心医院临床药学科，莱阳 265200
- Publication Type:Journal Article
- Keywords:
Histamine antagonists;
Skin rash;
Angioneurotic edema;
Desloratadine citrate
- From:
Adverse Drug Reactions Journal
2024;26(4):244-245
- CountryChina
- Language:Chinese
-
Abstract:
A 64-year-old female patient received treatments such as antibacterial, analgesic, etc. due to local swelling and blisters caused by application of domestically made drug for external use for knee joint pain. After 7 days, local skin redness and swelling appeared, with scattered rashes. Anti-allergic treatments including intravenous infusion of calcium gluconate and oral desloratadine cirate were given. On the second day, the patient developed a wheal like rash all over her body, and intravenous infusion of anti-allergic drugs were continued. On the same day, the patient′s skin symptoms were improved. The patient′s systemic rash worsened again after 1.5 hours of reapplication of desloratadine cirate, and the next day, angioneurotic edema appeared. Desloratadine cirate was stopped, dexamethasone, promethazine, and other symptomatic treatments were continued. Four days later, the patient′s symptoms completely disappeared.
