Effect of intravenous application of furosemide on occurrence of acute kidney injury in patients after cardiac surgery
10.3760/cma.j.cn114015-20231109-00789
- VernacularTitle:心脏外科手术后静脉应用呋塞米对患者发生急性肾损伤的影响
- Author:
Caixia FAN
1
;
Kun XU
;
Hongyan LI
;
Wenqi LIU
;
Zongfa ZHU
;
Zhengrong LI
;
Yunyan BI
;
Shilin ZHANG
;
Xiaosong ZHU
;
Shiming WANG
Author Information
1. 临沂市人民医院药学部，临沂 276000
- Publication Type:Journal Article
- Keywords:
Cardiac surgical procedures;
Furosemide;
Renal insufficiency;
Risk factors
- From:
Adverse Drug Reactions Journal
2024;26(4):198-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of intravenous application of furosemide on occurrence of cardiac surgery-associated acute kidney injury (CSA-AKI) in patients after cardiac surgery.Methods:The electronic medical records of patients undergoing cardiac surgery in Linyi People′s Hospital from January 2014 to December 2022 were collected and retrospectively analyzed. According to whether CSA-AKI occurred after surgery, the patients were divided into AKI group and non-AKI group and the clinical characteristics between the 2 groups were compared. Multivariate logistic regression was used to analyze the influencing factors of CSA-AKI, and the odds ratio ( OR) and its 95% confidence interval ( CI) were calculated. Results:A total of 2 633 patients were enrolled in the analysis, including 1 601 males (60.8%) and 1 032 females (39.2%). The age was (62.8±8.9) years, ranging from 18 to 85 years. Among the 2 633 patients, 491 (18.6%) developed CSA-AKI. Multivariate logistic regression analysis showed that after adjusting for factors such as the type of operation, intraoperative cardiopulmonary bypass, hypertension, diabetes mellitus, hypoalbuminemia, NYHA cardiac function class Ⅲ/Ⅳ, intraoperative/postoperative aortic balloon counterpulsation, preoperative serum creatinine level, operation duration, and the number of vasoactive drugs used after the operation, postoperative intravenous application of furosemide was still independently associated with the occurrence of CSA-AKI ( OR=2.161, 95 %CI: 1.720-2.715, P<0.001). Conclusions:The incidence of CSA-AKI in patients enrolled in this study was 18.6%. Intravenous use of furosemide after cardiac surgery can increase the risk of CSA-AKI.
