Correlation Between Cortical Thickness and Putamenial Dopamine Transporter in Parkinson's Disease
10.3969/j.issn.1005-5185.2025.03.010
- VernacularTitle:帕金森病大脑皮层厚度与壳核多巴胺转运体的相关性
- Author:
Jing WANG
1
;
Jingjie GE
;
Xia BAI
;
Ping WU
;
Yuhua ZHU
;
Jiaying LU
;
Huamei LIN
;
Huiwei ZHANG
;
Zhengwei ZHANG
;
Chuantao ZUO
Author Information
1. 复旦大学附属华山医院核医学/PET中心,上海 200235
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Positron-emission tomography;
Magnetic resonance imaging;
Dopamine transporter;
Brain cortical thickness
- From:
Chinese Journal of Medical Imaging
2025;33(3):280-285
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the cortical thickness features in Parkinson's disease(PD)patients at various stages and their association with dopamine transporter(DAT)levels in the putamen.Materials and Methods We retrospectively enrolled 30 PD patients and 15 healthy subject who underwent 11C-CFT PET and T1 MRI scans at the Department of Nuclear Medicine/PET Center of Huashan Hospital from August 2016 to October 2020.DAT average radioactivity in the anterior and posterior putamen was analysis using SPM12 software,with the occipital lobe as the reference region.Cortical segmentation and reconstruction were performed on T1 images using Freesurfer v7.2.The differences in cortical thinning between the groups were compared using a general linear model.Additionally,the relationship between cortical thickness in various brain regions and DAT uptake in the putamen were assessed.Results Compared to healthy subjects,significant cortical thinning was observed in the left inferior parietal lobule and the right and left inferior middle frontal gyrus of PD patients(all P<0.05).There was a significant positive correlation between the cortical thickness of the left inferior parietal lobule and right inferior middle frontal gyrus and DAT uptake in the corresponding anterior/posterior parts of the putamen(r=0.30-0.47,all P<0.05).Furthermore,the DAT uptake in the right precentral gyrus was positively correlated with the ipsilateral posterior putamen,exhibiting a stronger correlation than on the contralateral side(r=0.32,P=0.029).Conclusion The results show that the thickness of the thinning cortex area in the PD patients correlates significantly positively with DAT levels in the putamen,highlighting the importance of the basal ganglia cortical circuit and providing a basis for further research into the neural mechanisms of PD.
