Progress in role of PANoptosis and programmed cell deaths in renal cell carcinoma
10.3969/j.issn.1000-4718.2025.07.017
- VernacularTitle:泛凋亡和程序性细胞死亡在肾细胞癌中的研究进展
- Author:
Shufen ZHOU
1
;
Yaming LÜ
;
Yangyang HAN
Author Information
1. 新疆医科大学基础医学院生物学教研室,新疆 乌鲁木齐 830017
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
PANoptosis;
apotosis;
pyroptosis;
necroptosis
- From:
Chinese Journal of Pathophysiology
2025;41(7):1400-1406
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma(RCC)is a malignant tumor that originates from the epithelial cells of the re-nal tubules,comprising 80%to 90%of all malignant renal tumors.With the dual pressures of population growth and ag-ing,both the incidence and mortality rates of RCC are on the rise.PANoptosis is a newly identified form of cell death,con-trolled by the PANoptosome complex,and exhibits characteristics of three programmed cell death pathways,pyroptosis,apoptosis,and necroptosis.Increasing research indicates that the occurrence of PANoptosis is associated with tumor devel-opment,suggesting its potential as a new therapeutic strategy for renal carcinoma.This article reviews the definition of PANoptosis,the structure of the PANoptosome protein complex,and its impact on the PANoptosis process.Additionally,it explores the interactions between PANoptosis,pyroptosis,apoptosis and necroptosis,and their effects on RCC.
