The Measurement of Health State Utilities Associated with Treatment Attributes of Hemophilia A Patients in China
- VernacularTitle:中国血友病A患者治疗属性相关的健康效用值测量
- Author:
Shixian LIU
1
;
Hao CHEN
;
Yingrong BAI
;
Yunhai FANG
;
Lei DOU
;
Shunping LI
Author Information
1. 山东大学齐鲁医学院公共卫生学院卫生管理与政策研究中心、国家卫生健康委员会卫生经济与政策研究重点实验室(山东大学)、山东大学健康偏好研究中心 山东 济南 250012
- Publication Type:Journal Article
- Keywords:
hemophilia;
health state utility;
time trade-off
- From:
Chinese Health Economics
2025;44(4):70-73,78
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Time trade-off was employed to measure health state utilities associated with treatment attributes of hemophilia A patients to provide parameters for economic evaluations.Methods:Patients were recruited through patient organization and blood center of Shandong to measure health state utility values for 10 health states.Results:The utility values of preventive treatments for severe,moderate,and mild hemophilia A were 0.644,0.738,and 0.815,respectively.Compared with injections at 2-day intervals,the utility values were increased by 0.044 and 0.092 at 3-and 4-day intervals,respectively.Taking"severe hemophilia A patients injected every 2 days"as the base state,the disutility values for spontaneous bleeding and traumatic bleeding were 0.226 and 0.172.The disutility values for mild,moderate,and severe bleeding were 0.052,0.159,and 0.476,respectively,and the magnitude of the decrease gradually increased.Conclusion:Treatment attributes have an impact on patient preferences and more attention should be paid in pharmacoeconomic evaluations.
