Acute liver injury induced by Weikening tablets (胃刻宁片)
10.3760/cma.j.cn114015-20230215-00089
- VernacularTitle:胃刻宁片致急性肝损伤
- Author:
Yanli MA
1
;
Pingping YUAN
;
Wanhui ZHANG
;
Meiying NING
;
Jing ZHAO
Author Information
1. 沧州市中心医院药学部，沧州 061001
- Publication Type:Journal Article
- Keywords:
Chemical and drug induced liver injury;
Weikening tablets;
Greater celandine
- From:
Adverse Drug Reactions Journal
2023;25(12):757-758
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old male patient took Weikening tablets 1.24 g thrice daily orally for gastric ulcer by himself. The patient did not take other drugs during the same period. After 1 month of medication, the patient developed the symptoms such as abdominal distension, yellowish sclera, yellowish urine, and fatigue. Laboratory tests showed alanine aminotransferase (ALT) 1 272 U/L, aspartate aminotransferase (AST) 507 U/L, total bilirubin (TBil) 59 μmol/L, and direct bilirubin (DBil) 34 μmol/L. Acute liver injury caused by Weikening tablets was considered. Then the drug was stopped and treatments such as liver protective, choleretic, and enzyme reduction drugs were given. Ten days later, the above symptoms disappeared, and the liver function reexamination showed ALT 163 U/L, AST 43 U/L, TBil 23 μmol/L, and DBil 17 μmol/L. One month later, the patient′s liver function test showed ALT 31 U/L, AST 24 U/L, TBil 14 μmol/L, and DBil 6 μmol/L. It was considered that the liver injury of the patient may be related to greater celandine contained in Weikening tablets.
