Analysis of the effect of pterygium excision combined with autologous limbal stem cell transplantation on patients with pterygium
10.16753/j.cnki.1008-2344.2025.02.008
- VernacularTitle:翼状胬肉切除术联合自体角膜缘干细胞移植术治疗翼状胬肉效果分析
- Author:
Daofeng YANG
1
;
Yingfei WANG
;
Jie LI
Author Information
1. 虞城县人民医院眼科,河南 虞城 476300
- Publication Type:Journal Article
- Keywords:
pterygium;
pterygium excision;
autologous limbal stem cell transplantation;
amniotic membrane transplantation;
corneal astigmatism
- From:
Journal of Shenyang Medical College
2025;27(2):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application value of pterygium excision(PE)combined with autologous limbal stem cell transplantation(LSCT)in the treatment of pterygium.Methods:The clinical data of 125 patients with pterygium admitted to Yucheng County People's Hospital from Feb 2021 to Feb 2023 were retrospectively analyzed.The patients were divided into two groups according to the surgical method,with 58 patients undergoing PE combined with amniotic membrane transplantation as the control group and 67 patients undergoing PE combined with LSCT as the observation group.The surgical-related indicators and postoperative complications were compared between the two groups,as well as the pre-and post-operative visual acuity,corneal parameters[corneal astigmatism,corneal fluorescein staining(FL)score],tear secretion function[tear film breakup time(BUT),Schirmer test].Results:The operation time,corneal wound healing time,regression time of hyperemia and edema,and suture removal time in the observation group were shorter than those in the control group(P＜0.01).The visual acuity level in the observation group was higher than that in the control group at 7 days,1 month,and 3 months after surgery(P＜0.05).The corneal astigmatism degree and FL score in the observation group were lower than those in the control group at 1 month and 3 months after surgery,while BUT and Schirmer test were higher than those in the control group(P＜0.05).There was no significant difference in the total incidence of complications between the two groups after surgery(P＞0.05).Conclusion:The combined treatment of PE and LSCT for pterygium is effective,which can accelerate the recovery process after surgery,improve corneal morphology and tear secretion function,enhance visual acuity,and ensure surgical safety.
