Rhabdomyolysis and acute kidney injury due to ibuprofen sustained-release capsules in patient with coronavirus disease 2019
10.3760/cma.j.cn114015-20230419-00287
- VernacularTitle:布洛芬缓释胶囊致新型冠状病毒感染患者横纹肌溶解症和急性肾损伤
- Author:
Hengfen DAI
1
;
Jingwen XIAO
;
Yu OUYANG
;
Haijuan HOU
;
Caiyun ZHENG
;
Yan ZHANG
Author Information
1. 福建医科大学附属福州市第一医院药学部，福州 350009
- Publication Type:Journal Article
- Keywords:
Coronavirus infections;
Ibuprofen;
Rhabdomyolysis;
Acute kidney injury
- From:
Adverse Drug Reactions Journal
2023;25(12):761-763
- CountryChina
- Language:Chinese
-
Abstract:
A 17-year-old female patient developed fever after novel coronavirus infection and took ibuprofen sustained-release capsules 0.3 g 4 times within 3 days by herself. During the medication, the patient developed the symptoms such as chest tightness, shortness of breath, limbs fatigue, sweating, muscle soreness, and dark urine successively. Laboratory tests showed creatine kinase (CK) 583 800 U/L, CK-MB 45 μg/L, lactate dehydrogenase 4 772 U/L, serum creatinine (Scr) 392 μmol/L, myoglobin 87 μg/L, and urea nitrogen 32.8 mmol/L. It was considered that rhabdomyolysis with acute kidney injury might be related to ibuprofen. The patient was given symptomatic treatments such as renal replacement therapy, hemodialysis, blood transfusion, rehydration, diuresis, etc. Thirty-three days later, the patient′s muscle soreness and other symptoms disappeared, the urine color returned to normal, laboratory tests showed CK 168 U/L, myoglobin 24 μg/L, and Scr 52 μmol/L.
