Cleft lip and palate deformity in twin fetus after diphenhydramine exposure during pregnancy
10.3760/cma.j.cn114015-20210601-00620
- VernacularTitle:孕期苯海拉明暴露后双胎唇腭裂畸形
- Author:
Haixia SONG
1
;
Qin QIN
1
;
Caixia YUAN
1
;
Lingling FAN
1
;
Hong LI
1
Author Information
1. 山西省人民医院生殖医学科，太原 030012
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Diphenhydramine;
Maternal exposure;
Cleft lip;
Cleft palate
- From:
Adverse Drug Reactions Journal
2022;24(2):110-112
- CountryChina
- Language:Chinese
-
Abstract:
A 38-year-old female underwent in vitro fertilization and embryo transfer for bilateral tubal obstruction secondary infertility. Seven days after embryo implantation, the patient developed severe nausea, vomiting, and vertigo. Human chorionic gonadotropin test in blood was positive, so the woman was diagnosed as having biochemical pregnancy and early pregnancy reaction. After symptomatic treatment, the symptoms of vertigo were not improved and gradually aggravated. Intramuscular injection of diphenhydramine 20 mg was given at 3 +2 weeks of gestation. Then the symptoms were relieved. At 24 weeks of gestation, the patient was diagnosed as having twin pregnancy and cleft lip in twin fetus, and fetus cleft palate could not be excluded. After the above diagnosis was confirmed at 28 weeks of gestation, induction of labor was performed in the patient. Both fetuses were found to have severe cleft lip and palate, and no other appearance of deformities was found. It was considered that the cleft lip and palate deformity in the twin fetus might be related to diphenhydramine exposure during pregnancy.
