The relationship between SERPINA4 expression and prognosis in metastatic color-ectal cancer
10.13315/j.cnki.cjcep.2025.03.010
- VernacularTitle:转移性结直肠癌中SERPINA4表达与预后的关系
- Author:
Jianfang GAO
1
;
Xiaotong DONG
;
Qing ZHAO
;
Yunxiang ZHANG
;
Huimin SUN
Author Information
1. 山东第二医科大学第一附属医院/潍坊市人民医院精准病理诊断中心,潍坊 261041;山东第二医科大学基础医学院,潍坊 261053
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
metastasis;
SERPINA4;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(3):340-344,351
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the relationship between SERPINA4 expression and clinicopathological fea-tures and prognosis in metastatic colorectal cancer(CRC).Methods EnVision two-step immunohistochemical method was used to detect the expression of SERPINA4 protein in 104 cases of primary and metastatic tumor paraffin tissues of metastatic colorectal cancer and adjacent intestinal normal mucosa,and its relationship with clinicopathological features of patients was analyzed.qRT-PCR was used to detect the expression of SERPINA4 mRNA in 11 pairs of metastatic CRC metastases and paired primary tumor paraffin-embedded tissue samples.The survival of patients was followed up,and the relationship between SERPINA4 expression and patient prognosis was analyzed by Kaplan-Meier method.Re-sults Immunohistochemical results showed that the strong positive expression rate of SERPINA4 was 97.10％in nor-mal mucosa,71.20％in primary lesions,and 39.40％in metastatic lesions.The difference between the three groups was statistically significant(P＜0.001).qRT-PCR results showed that SERPINA4 mRNA was lowly expressed in me-tastatic lesions of metastatic CRC(P＜0.05).The expression of SERPINA4 in metastatic lesions was significantly cor-related with histological grade,N stage and M stage of the tumor(P＜0.05),but not significantly correlated with age,gender,tumor location and T stage of patients(P＞0.05).The survival time of patients with metastatic colorectal cancer with high expression of SERPINA4 was longer than that of patients with low expression.Conclusion The ex-pression of SERPINA4 is of great significance in the survival and prognosis of patients with metastatic CRC.
