Drug fever caused by levothyroxine sodium tablets

VernacularTitle:左甲状腺素钠片致药物热
Author: Liping YU ¹ ; Xiangjun PENG ; Jie CHEN ; Ping WANG ; Chuanzhou ZHANG
Author Information

1. 山东省日照市第二人民医院药学部，日照　276807
Publication Type:Journal Article
Keywords: Fever; Drug-related side effects and adverse reactions; Levothyroxine sodium
From: Adverse Drug Reactions Journal 2022;24(2):92-93
CountryChina
Language:Chinese
Abstract: A 75-year-old female patient underwent total thyroidectomy and neck lymph node dissection for thyroid malignant tumor. In order to supplement thyroid hormone after operation, the patient was given levothyroxine sodium tablets 100 μg by nasal feeding once daily. On the 5th day of treatment, the patient developed fever, with highest body temperature 39.0 ℃. The levothyroxine sodium were stopped, then her body temperature decreased to 36.2 ℃ the following day. After giving nasal feeding of levothyroxine sodium tablets again or oral levothyroxine sodium tablets produced by other manufacturers, fever recurred in the patient and the body temperature returned to normal after drug withdrawal. It was considered that the patient′s fever was drug fever caused by levothyroxine sodium tablets.