Liver injury caused by raw Dioscorea bulbifera L.
10.3760/cma.j.cn114015-20210518-00587
- VernacularTitle:生食黄独零余子致肝损伤
- Author:
Yan WANG
1
;
Yuanyuan FEI
;
Huichun JI
Author Information
1. 宿迁市第一人民医院感染科，宿迁 223800
- Publication Type:Journal Article
- Keywords:
Dioscorea;
Plant poisoning;
Chemical and drug induced liver injury;
Liver Cirrhosis;
Dioscorea bulbifera L.
- From:
Adverse Drug Reactions Journal
2022;24(1):37-39
- CountryChina
- Language:Chinese
-
Abstract:
A 34-year-old female patient intermittently ate 7 or 8 raw Dioscorea bulbifera L. due to rhinitis. After a 1-year interval, she ate 1 raw Dioscorea bulbifera L. again. Four days later, the patient developed nausea and yellowish skin and sclera. Laboratory tests showed alanine aminotransferase (ALT) 732 U/L, aspartate aminotransferase (AST) 597 U/L, gamma glutamine transferase (γ-GT) 204 U/L, alkaline phosphatase (ALP) 202 U/L, total bilirubin (TBil) 203.7 mmol/L, and direct bilirubin (DBil) 122 mmol/L. Abdominal magnetic resonance imaging showed early liver cirrhosis, and liver transient elastography showed early liver fibrosis. The liver injury caused by viral hepatitis, autoimmune hepatitis, hepatolenticular degeneration, abnormal iron metabolism and other reasons was excluded by various laboratory examinations. It was considered that the liver injury was associated with Dioscorea bulbifera L. Then liver-protective drugs such as magnesium isoglycyrrhizinate injection, polyene phosphatidylcholine injection, reduced glutathione for injection, ademetionine 1,4-butanedisulfonate for injection, and ursodeoxycholic acid were given. Forty-two days later, the patient′s symptoms disappeared basically and laboratory tests showed TBil 55.3 mmol/L, DBil 18.1 mmol/L, ALT 24 U/L, AST 25 U/L, γ-GT 44 U/L, and ALP 124 U/L.
