Research progress in pathophysiological mechanism and treatment of chemotherapy-induced neuropathic pain
10.3760/cma.j.cn114015-20210223-00207
- VernacularTitle:化疗所致神经病理性疼痛的病理生理机制及治疗研究进展
- Author:
Gangqi YANG
1
;
Wanting LU
;
Yinying LU
;
Fei LI
;
Hongyan LI
Author Information
1. 首都医科大学宣武医院普通外科，北京 100053
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Chemotherapy, adjuvant;
Pain management;
Neuroprotection
- From:
Adverse Drug Reactions Journal
2022;24(1):30-34
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy-induced neuropathic pain (CINP) is a common adverse reaction in cancer chemotherapy, which is dose-dependent. CINP initially presents as acute pain syndrome and can lead to chronic neuropathic pain if not cured or recurrent. The pathophysiological mechanisms of CINP include mitochondrial dysfunction, calcium dyshomeostasis, oxidative stress, activation of apoptotic pathways, loss of myelin and non-myelin fibers, activation of the immune system, and increased expression of ion channels, etc. The mechanism of neuropathic pain induced by different chemotherapeutic drugs is different. There is a lack of effective CINP control measures and the highly recognized therapeutic drug is serotonin and norepinephrine reuptake inhibitor duloxetine.
