Delirium induced by dexmedetomidine
10.3760/cma.j.cn114015-20210120-00085
- VernacularTitle:右美托咪定致谵妄
- Author:
Zhihong QIU
1
;
Longxi PENG
;
Xiaoming LI
Author Information
1. 河北省人民医院药学部，石家庄 050051
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Delirium;
Drug-related side effects and adverse reactions
- From:
Adverse Drug Reactions Journal
2021;23(11):605-606
- CountryChina
- Language:Chinese
-
Abstract:
An 81-year-old male patient with bipedal blue toe syndrome received IV pumping of dexmedetomidine 0.2 mg dissolved in 0.9% sodium chloride injection 48 ml at the rate of 4 ml/h once daily because of severe pain in his left toe. The patient developed irritability and delirium about 6 hours after the 3rd IV pumping. The next day, the pain was relieved and dexmedetomidine was stopped. After drug withdrawal, the patient occasionally had delirium. Due to difficulty in falling asleep, the same dose of dexmedetomidine was given again on the 3rd day of drug withdrawal. The same dose of dexmedetomidine was given twice the next day and obvious delirium and irritability occurred 2-3 hours after drug administration of each time. Delirium was suspected to be related to dexmedetomidine. Dexmedetomidine was stopped again and replaced by tramadol and midazolam. On the 6th day of drug withdrawal, the patient′s consciousness turned clear, and no delirium recured.
