Gastric cancer featuring bidirectional differentiation into glandular and neuroen-docrine tissues:a clinicopathological analysis of 12 cases
10.13315/j.cnki.cjcep.2025.03.006
- VernacularTitle:胃具有腺和神经内分泌双向分化的癌12例临床病理学观察
- Author:
Yihui MA
1
;
Jiajing LI
1
;
Hui QIN
1
;
Feng WANG
1
;
Yingzi WANG
1
;
Xia PANG
1
;
Chenfei LI
1
;
Shanshan LI
1
Author Information
1. 郑州大学第一附属医院病理科,郑州 450052
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
adenocarcinoma;
neuroendocrine carcinoma;
amphicrine
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(3):311-316
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinical and pathological characteristics of gastric amphicrine carcinoma(AC).Methods Clinical data of 12 patients with gastric AC were collected,and their clinical pathological character-istics and histological morphology were observed.Immunohistochemical staining,special staining,and electron micros-copy techniques were used to analyze their immune phenotype and ultrastructure.Molecular pathology was used to de-tect microsatellite status.Relevant literature was reviewed.Results Ten cases of gastric AC were located at the junc-tion of the esophagus and stomach/cardia,1 case at the gastric angle,and 1 case in the gastric antrum.The average maximum diameter of tumors was 4.25 cm.There were different proportions of tumor cells with signet-ring like charac-teristics in all cases.Four cases had neuroendocrine carcinoma components,and another 4 had adenocarcinoma.Elev-en cases had nerve invasion and vascular cancer thrombus.Eleven cases invaded the serosal layer/submucosal layer,and 1 case invaded the submucosal layer.Ten cases had lymph node metastasis.All 12 cases showed diffuse expression of CKpan and Syn,with 3 cases showed diffuse expression of CgA and 7 cases showed diffuse expression of CD56.The average proliferation index of Ki67 was 78.9％.Special staining showed clear intracellular mucus.Electron microscopy examination revealed electron dense particles and mucus particles within the tumor cells.A total of 10 patients were fol-lowed up,of which 7 survived,and 3 patients died from multiple systemic metastases at 0,24,and 30 months postop-eratively.Conclusion Gastric AC was more common in the junction of the esophagus and stomach/cardia,and histol-ogy shows a higher invasiveness.Their clear diagnosis depends on histological morphology,immunohistochemistry,and special staining.
